GO:0005852 cellular_component eukaryotic translation initiation factor 3 complex
| PAG Title | GO:0005852 cellular_component eukaryotic translation initiation factor 3 complex |
| PAG ID | TAX015972 |
| Type | A |
| Source Link |  GOA |
| Publication Reference | NA |
| PAG Description | A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. |
| Species | Homo sapiens |
| nCoCo Score | 6,521 |
| Base PAG ID | TAX015972 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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